High or very high levels of negative predictive value for detecting cervical cancer precursors, regardless of the threshold taken (HSIL(CIN2+) or HSIL(CIN3+)), in most other studies and in our observed at a level higher than 90% or higher than 95% [15,21,25], suggest high safety of women with HPV-positive status and with negative p16/Ki67 test result. This evidence concerns the gene MKI67 and cervical cancer.