For example, whereas IL-17-producing CD4+ T-cells from LR-MDS patients are increased and Tregs number and function are reduced [87], HR-MDS patients display quantitative and qualitative alterations of CD8+ T-cells [88], NK-cells [70], and an expansion of Tregs [89,90] and MDSCs. This evidence concerns the gene CD4 and myelodysplastic syndrome.