Moreover, the use of a chimeric IgG mouse-human monoclonal antibody against Hsp60 altered the course of experimental histoplasmosis and paracoccidioidomycosis, increasing phagolysosomal fusion and enhancement of yeast phagocytosis by macrophages in vitro and reducing the fungal burden in a murine model of intranasal infection with H. capsulatum [102]. This evidence concerns the gene HSPD1 and paracoccidioidomycosis.