Interestingly, broader/greater roles of Set2 and Ash1 in the catalysis of H3K4me than of H3K36me suggest that both of them function like Set1 and hence involve in sequential activation of cre1 required for carbon catabolite repression in association with the utilization of insect nutrients and of hyd1 and hyd2 essential for conidial hydrophobicity and infection-required adherence to insect cuticle, as discussed below. This evidence concerns the gene SETD2 and infection.