Pneumocystis infection appears to be associated with dysfunction of the IL-23/IL-17 axis, with higher lung fungal burdens and reduced production of IL-17 and chemokines CXCL10 (IP-10), CCL3, CCL4, and CCL5 [48], all crucial for infection resolution [45]. This evidence concerns the gene CXCL10 and Pneumocystis infectious disease.