Hence, in the present study, we characterized the main phenolic substances in green pea hull (GPH) extracts by UHPLC-LTQ-OrbiTrap-MS, and assessed the effects of GPH phenolic extracts on UC and gut microbiota based on the Keap1-Nrf2 signaling pathway, using a DSS-induced mouse colitis model. This evidence concerns the gene KEAP1 and colitis.