Among food-induced anaphylaxis, cows’ milk allergy (CMA) is an anaphylactic response arising from whey protein such as α-lactalbumin (ALA), primarily mediated by IgE, which can arouse cell degranulation, and then trigger diarrhea, gastroduodenal bleeding, asthma, etc. [8,9]. Here, IGHE is linked to anaphylaxis.