A tumor-promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) activated the mitogen-activated protein kinases pathway (MAPK) via phosphorylation of extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) and p38 [52], which leads to Epstein Barr virus (EBV) expression and eventually cell deformation. This evidence concerns the gene MAPK3 and neoplasm.