Exercise can promote the expression of anti-inflammatory cytokine and inhibit the expression of pro-inflammatory cytokines, inhibit the IKK/NF-KB signal transduction pathway, downregulate the signal transduction of the Toll-like receptors, reduce the phosphorylation of JNK and expression of TNF-α, so as to reduce fat content and improve skeletal muscle inflammation and insulin resistance [47]. The gene discussed is MAPK8; the disease is Insulin resistance.