INS and substance abuse: While the relationship between substance abuse and insulin/vitamin intake is not clear, ref. [29] found that insulin pathway have an effect on the central nervous system, which in return could make a person more inclined towards “craving”, and [30], a case study, warns against the unexpected abuse of Vitamin D. Thus, based on these observations and based on the results presented in Section 3, we conclude that the proposed SEI developmental route is promising and warrants further investigation and work for deeper insights.