The CDK4/6 inhibitors (CDK4/6i) Palbociclib, Ribociclib, and Abemaciclib have recently gained FDA-approval and shown success in the treatment of advanced metastatic hormone receptor-positive (HR+)/HER2-negative breast cancer [15], with several clinical trials now testing their effects in multiple tumour types. Here, NR4A1 is linked to breast cancer.