Therefore, this study aims to provide an up-to-date review of the role, prevalence and significance on patient survival of CDK4 in PC, in relation to understanding the potential efficacy of CDK4/6 inhibitors as a combined treatment option with chemotherapy for PC patients by evaluating the current epidemiology of PC and the expression levels of CDK4 in PC tissues, obtained from open-access online databases. This evidence concerns the gene CDK4 and pachyonychia congenita.