Reduced expression of JAK, IFN, and ER stress response signaling pathway factors was further observed in RIG-I knockdown cells, which suggested that RIG-I could be a target receptor in regulating the IFN/JAK2 and ER stress response to induce apoptosis and, consequently, inhibit chemoradiation resistance in NPC [86]. The gene discussed is IFNA1; the disease is nasopharyngeal carcinoma.