On the one hand, a meta-analysis of 12 studies of VNTR of the DRD4 gene polymorphism with depression performed by López León et al. (2005) revealed that the short allele 2 is associated with depression [22], but on the other hand, Gafarov et al. [23] found that male carriers of the 4R/6R genotype of the DRD4 gene were more likely to be found amongst subjects with a severe level of anxiety and depression and the carriers of the DRD4 allele 6R were more common among males diagnosed with depression. This evidence concerns the gene DRD4 and depressive symptom measurement.