Furthermore, Souchet and collaborators [48] demonstrated that the cleaved form of DYRK1A is present in astrocytes in the hippocampus of AD patients and APP/PS1 mice, although proteolysis in their case was not associated with a modification of global DYRK1A kinase activity but was associated with a reduced kinase specificity and a stronger affinity towards STAT3a, an activator of neuroinflammation. This evidence concerns the gene APP and Alzheimer disease.