MAPT and Mental deterioration: P53, the tumor suppressor protein, and P44, a shortest form, whose overexpression causes premature aging in mice [27] with cognitive decline, synaptic defects, and MAPT/TAU hyperphosphorylation [28], were found to bind to the promoter of Dyrk1a and activate its transcription as well as the transcription of other kinases known to be involved in MAPT/TAU phosphorylation [29].