DS is a multigenic diseases with many overdosage genes, such as Kcnj6 (Potassium Inwardly Rectifying Channel Subfamily J Member 6), App (Amyloid-β precursor protein), (Cystathionine β synthase) and others, contributing to cognitive phenotypes [160,234,235]. The gene discussed is KCNJ6; the disease is Dravet syndrome.