Phosphorylation of the splicing factors ASF, SC35 and SRp55 by DYRK1A prevents the promotion of Mapt/Tau exon 10 inclusion by those factors leading to an overproduction of the 3R-TAU form at the expanse of the 4R-TAU, leading to of 3R/ 4R TAU ratio imbalance, exacerbating AD disease [121,123,124]. This evidence concerns the gene MAPT and Alzheimer disease.