Tyr 145 and 147 phosphorylated and nonphosphorylated forms of DYRK1A were described in the brains of human and mouse with DS, with phosphorylation of those two tyrosines being abundant in the neuronal cytoplasm of postnatal brains but low in nuclei of astroglial cells, adult hippocampal progenitors and some cholinergic axon terminal [42]. The gene discussed is DYRK1A; the disease is Dravet syndrome.