Indeed, since exercise may promote health and enhance systemic health via various cellular responses (e.g., metabolic change, bone, regeneration, anti-cancer, anti-inflammatory and regulation of muscle mass and function) that have been shown to implicate SPARC, SPARC comes out as a molecular mediator secreted following exercise to enhance and stimulate biological properties and endogenous processes toward a healthy homeostatic phenotype. This evidence concerns the gene SPARC and cancer.