The analysis, which included 14,746 African Americans, found a novel SNP associated with total stroke in the 15q21.3 locus which is located near the Aquaporin 9 gene (AQP9), the aldehyde dehydrogenase 1 family, member A2 (ALDH1A2) and hepatic lipase (LIPC) genes. This evidence concerns the gene AQP9 and stroke disorder.