In addition, the APOE locus which has been associated with lobar and deep Intracerebral Hemorrhage (ICH) in European populations [47] does not have an independent effect in Hispanics or individuals of African Ancestry, according to a large meta-analysis of 11 hospital and population-based studies in Europe and the US, although other multiethnic studies have reported conflicting results regarding the role of the specific alleles in hemorrhagic stroke risk across different ethnicities [48,49]. This evidence concerns the gene APOE and intracerebral hemorrhage.