Then, key genes EDN1, EP300, MAPK3, and TNF were selected for the targeted network and validated by other GEO datasets (Supplementary Figure S1A,B) and other public databases to be related to STING signaling, cytokine response, and NAFLD/NASH pathogenesis (Supplementary Figures S2 and S3). This evidence concerns the gene EDN1 and metabolic dysfunction-associated steatohepatitis.