Based on the diagnostic performance analysis of this RNAs panel, we concluded that the circulatory EDN1 Regulating RNAs panel could enable us to discriminate NAFLD/NASH cases from controls, and also NAFLD/NASH cases with early (F1, F2) from advanced Fibrosis (F3, F4) (Figure 6). The gene discussed is EDN1; the disease is metabolic dysfunction-associated steatotic liver disease.