Maternal zygotic ptk7 (MZptk7) and zygotic ptk7 (Zptk7) mutant zebrafish develop spinal curvatures that model congenital scoliosis (CS) and adolescent idiopathic scoliosis (AIS), respectively, due to differential timing of ptk7 loss-of-function [2,11]. The gene discussed is PTK7; the disease is adolescent idiopathic scoliosis.