PTK7 and Cowden syndrome 1: Maternal zygotic ptk7 (MZptk7) and zygotic ptk7 (Zptk7) mutant zebrafish develop spinal curvatures that model congenital scoliosis (CS) and adolescent idiopathic scoliosis (AIS), respectively, due to differential timing of ptk7 loss-of-function [2,11].