Hyperferritinemia with iron overload includes hemochromatosis (HH) due to mutation in HFE, HJV, HAMP, TFR2 and SLC40A1 gain-of-function mutations, hereditary iron loading anemias, and hypo-transferrinemia that are characterized by high TSAT [2]. The gene discussed is HAMP; the disease is isolated hyperferritinemia.