Naturally occurring canine models exist for several IRDs, some of which have contributed to gene augmentation therapies in humans, such as the Rpe65 model for Leber congenital amaurosis (LCA) [2], and the Pde6a [3] and Pde6b [4] models for autosomal recessive RP phenotypes. This evidence concerns the gene RPE65 and Leber congenital amaurosis.