The current study is ongoing, we will continue to recruit subjects to increase statistical power and conduct a more specific analysis, such as associations between APOE ε4 allele or its genotypes (ε4/ε4, ε3 ε4 or ε3/ε2, etc) and several cholesterol related phenotypes (e.g., hypertension, thyroid disease). This evidence concerns the gene APOE and thyroid gland disorder.