RAF1 and Noonan syndrome: Although iPSC lines are a valuable resource for neurodevelopmental disease research, so far most of the cell lines generated for the various genes associated with Noonan syndrome have only been studied in the context of the Noonan-associated cardiomyopathy (RAF1 [162,163], LZTR1 [164], MRAS [165]) and juvenile myelomonocytic leukemia (PTPN11 [166]).