SYNGAP1 and Noonan syndrome: In mouse models for NF1 (Nf1+/− mice), Noonan syndrome (Ptpn11D61G/+ mice) and SYNGAP1-ID (Syngap1+/− mice) lovastatin successfully ameliorates the cognitive deficits, restoring normal protein synthesis, improving memory and spatial learning [111,130,180].