When only male Ts65Dn,Dyrk1a+/+/+, Ts65Dn,Dyrk1a+/+/Osx-Cre, Eu,Dyrk1a+/+, and Eu,Dyrk1a+/Osx-Cre mice were compared for the effects of the extra chromosomal material (ploidy) and the effects of Dyrk1a copy number in osteoblasts (Dyrk1a), euploid mice had stronger trabecular parameters than trisomic mice for BMD (p = 0.009), BV/TV (p = 0.0127), Tb.Th (p = 0.018), Tb.N (p = 0.0386), and Tb.Sp (p = 0.0451), consistent with previous studies in Ts65Dn and Dp1Tyb male DS mouse models [20,33] (Figure 1). The gene discussed is DYRK1A; the disease is Dravet syndrome.