TLR9 and pregnancy disorder: A further analysis showed that different double-, triple- and quadruple-SNP variants for the studied polymorphisms with C alleles in CSF2 rs25881, FLT1 rs722503, TFPI C-399T SNPs and the T allele in TLR9 rs352140 polymorphism were significantly more frequent in the women with pPROM compared to the PROM subjects, after adjusting for APTT, PLT parameters and pregnancy disorders (p ≤ 0.050, see Tables S9 and S10).