An additional comparison between the pPROM and tPROM cases showed that the C alleles for the CSF2, FLT1 and TFPI polymorphisms, and the T allele for the TLR9 SNP in different complex variants, were more common in the women with pPROM after adjusting for APTT, PLT parameters and pregnancy disorders. This evidence concerns the gene TLR9 and pregnancy disorder.