TLR9 and pregnancy disorder: Adjusting the results for pregnancy disorders also revealed that the TT variants for CSF2 and FLT1 SNPs were associated with an approximately two-fold increase in the pPROM risk (p ≤ 0.050, see Table 4), while the TCT complex variants for the CSF2, FLT1 and TLR9 SNPs correlated with a reduced risk of disease, corrected by a serological conflict (OR 0.01 95% CI 0.00–0.05, p ≤ 0.001, see Table 4).