CD4 and neoplasm: Subsequently, we found that several immune-related signaling pathways were upregulated in the CSMD1-mut samples; that there was a higher proportion of anti-tumor immune cells including CD4+ Th1 cells, NK cells, M1 macrophage cells and PDC; that there was a lower proportion of tumor-promoting immune cells, including Treg cells, M2 macrophage cells, and endothelial cells; and that there was upregulation of PD-L1.