We found an association between KCNQ4 and aortic aneurysm (OR: 4.97, p = 6.3 × 10−4), fracture of lower limb (OR: 3.31, p = 7.1 × 10−4) and polyneuropathy in diabetes (OR: 7.67, p = 8.4 × 10−4). The gene discussed is KCNQ4; the disease is aortic aneurysm.