To explore whether circ_0092367 can modulate the expression of cleaved-caspase-3, CD133, and MDR1 in PC cells, we performed Western blotting analysis and found that the overexpression of circ_0092367 in PaCa-2 cells increased the protein levels of cleaved-caspase-3, but reduced the expression of CD133 and MDR1. This evidence concerns the gene PROM1 and pachyonychia congenita.