For instance, serum MUC3A is a potential diagnostic biomarker for extrahepatic cholangiocarcinoma [11]; high expression of MUC3A is associated with localized clear-cell renal cell carcinoma [12]; bone marrow MUC4 expression had significant prognostic value in acute myeloid leukaemia [13]. This evidence concerns the gene MUC3A and clear cell renal carcinoma.