SRSF6 and pulmonary arterial hypertension: This intronic insertion is located at the 5′ end of intron 12 of PAH, and although it does not directly disturb the canonical donor splice site, the in silico evaluation agrees with the diminished recognition of the intron 12 donor splice site (MaxEntScan: −42.9%, NNSPLICE: −8.8%, SpliceSiteFinder-like: −6.4%, GeneSplicer: −100%; ESEFinder: abolition of a splicing intronic enhancer element recognized by SRp55).