Furthermore, Chip-seq data showed that the MADS box transcription factors SEP3, AG, PI, AP1, and AP3 bind to the CRC promoter suggesting their involvement in regulating CRC expression, such that SEP3 together with AG as tetramers activate CRC expression, and AP3 and PI repress CRC expression in the stamen and petal whorl [25,26,27,28,29,30]. The gene discussed is RENBP; the disease is colorectal carcinoma.