SPP1 and intrahepatic cholangiocarcinoma: For instance, eIF3C and KI67 may be valuable predictors of survival and recurrence of ICC patients [6], NR4A2/OPN/Wnt signaling axis may be a pivotal executor of hepatic stellate cells instigated cancer-promoting roles in ICC [7], typing FGFR2 translocation can determine the response to targeted therapy of intrahepatic cholangiocarcinoma [8], and DKK-1 combined with CA 19-9 may be the potential diagnostic and prognostic marker that may be better than CA 19-9 alone [9].