Blockade of CXCL12/CXCR4 signaling can inhibit ICC progression and metastasis through inactivation of canonical Wnt pathway [10], lncRNA MT1JP has a protective role via regulating miR-18a-5p/FBP1 axis [11], and crenigacestat, a selective NOTCH1 inhibitor, can reduce ICC progression via blocking VEGFA/DLL4/MMP13 axis [12]. This evidence concerns the gene NOTCH1 and intrahepatic cholangiocarcinoma.