We observed that deletion of Nrf2 resulted in the downregulation of several proteins, including the outer mitochondrial membrane protein Cpt1; Cytoplasmic Aconitase and Cat; proteins from complex I (NADH dehydrogenase), including Ndufa6, Ndub6, Ndufb7, Ndufa12, Ndufs7, Ndufs4, Ndufb8, and Ndufb9 as well as the downregulation of the mitochondrial Fis1 protein that is implicated in Alzheimer’s disease. This evidence concerns the gene ACO1 and early-onset autosomal dominant Alzheimer disease.