NDUFS4 and early-onset autosomal dominant Alzheimer disease: We observed that deletion of Nrf2 resulted in the downregulation of several proteins, including the outer mitochondrial membrane protein Cpt1; Cytoplasmic Aconitase and Cat; proteins from complex I (NADH dehydrogenase), including Ndufa6, Ndub6, Ndufb7, Ndufa12, Ndufs7, Ndufs4, Ndufb8, and Ndufb9 as well as the downregulation of the mitochondrial Fis1 protein that is implicated in Alzheimer’s disease.