CD28 and type 1 diabetes mellitus: Several genes involved in immune responses in patients with type 1 diabetes were hypermethylated in umbilical cord blood-derived monocytes, including signal transducer and activator of transcription 1 (STAT1), T cell receptors (CD247, CD28, and CD3E), MHC I class or II subunits (HLADMB and HLA-DQB1) [79].