Previous studies also observed that maternal obesity may influence the prevalence of offspring obesity, which may be mediated by the methylation of promoter DNA of three key genes related to metabolic syndrome (PPARGC1A, PPARG, and mitochondrial transcription factor A (TFAM)), as identified in umbilical cord blood [52,67]. This evidence concerns the gene PPARGC1A and obesity due to melanocortin 4 receptor deficiency.