Several imprinted genes involved in metabolic diseases such as PPARα [54], IGF2 [109], H19 [109], and paternally expressed gene 3 (Peg3) [110] are differentially methylated in the mammalian gametes in oocytes of control and obese animals and their offspring, which suggests that maternal obesity can induce transgenerational inheritance of metabolic disease through DNA methylation. This evidence concerns the gene IGF2 and metabolic disease.