Human and animal studies also showed that maternal obesity or overnutrition during conception or lactation can modulate DNA methylation of different genes involved in energy metabolism, glucose homeostasis, insulin signaling and fat deposition, which support the role of DNA methylation in maternal obesity-induced risk of NAFLD, obesity, diabetes, and CKD (Table 1) [48,49,50,51,52,53]. The gene discussed is INS; the disease is chronic kidney disease.