CD8A and obesity due to melanocortin 4 receptor deficiency: Additional studies have found that the TAP-binding protein (TAPBP) is hypermethylated in umbilical cord blood of obese mothers, which suggests that maternal obesity can result in the development of obesity in the offspring via reducing tapasin (decreased tapasin can lower CD8 + T-cell responses in vitro) leading to impaired immune responses in offspring [71,72].