DNA methylation levels in the promoters of the glycerol-3-phosphate acyltransferase 1 (GPAT1) is lower and the transcriptome level of GPAT1 and SREBP-1 are higher in the offspring of obese mothers compared to offspring of normal weight mothers, in association with increased hepatic triglyceride levels [59,60] also suggesting increased risk of hepatic steatosis in the offspring [96]. Here, SREBF1 is linked to fatty liver disease.