Maternal obesity was found to alter the methylation level of hepatocyte nuclear factor-4 alpha (HNF4A), Peroxisome proliferator-activated receptor gamma coactivator (PPARGC)-1β as well as fibroblast growth factor (FGF)-21 in mice offspring liver, which have crucial roles in hepatic fibrosis and lipid accumulation [92,93]. The gene discussed is FGF21; the disease is Hepatic fibrosis.