Support for olfactory aplasia due to FAM149B1 dysfunction comes from mutations in other genes, associated with cilia function or structural integrity of cilia, and resulting in olfactory dysfunction, such as hypo- or anosmia in Bardet-Biedel-syndrome (BBS) [13,14,15], polycystic kidney disease [15], or rarely in OFD VI [8] and JS [16]. Here, FAM149B1 is linked to Kallmann syndrome.