While most of the published work continues to focus on the switch of E- to N-cadherin and its role in the epithelial–mesenchymal transition, other subsets of cadherins (cadherin 17, cadherin 5 and cadherin 6) that have an RGD (arginine–glycine–aspartic acid) binding site in the extracellular domains may play a role in tumor formation [50]. This evidence concerns the gene CDH5 and neoplasm.