When investigating the mechanism by which T cells from donors treated with the granulocyte colony-stimulating factor (G-CSF) show a reduced capacity to induce GVHD, a study featuring both in vitro and in vivo assays [16] (Table 6) reported that the expression of AKNA mRNA was significantly enhanced in CD4+CD25+ Treg cells. The gene discussed is CSF3; the disease is graft versus host disease.