AKR1B1 and diabetes mellitus: Molecular docking studies on (4Z, 12Z)-cyclopentadeca-4, 12-dienone have shown that this compound can inhibit the action of enzymes aldose reductase, glucokinase, pyruvate dehydrogenase kinase, receptor-gamma, glycogen synthase kinase-3, and fructose-6-phosphate amidotransferase with a role in diabetes.