SPARC and hepatocellular carcinoma: Importantly, with this expression specificity of SPARC within different pathological contexts, the potential implications of SPARC in pathogenesis are worthy of further exploration in order to identify new therapeutic targets, drugs, or adjuvants for metabolic disorders, inflammation, or cancer, especially because SPARC has been shown to play roles related to the cytotoxic effect of sorafenib against hepatocellular carcinoma cells [48].