Obesity, clinically evident as hyperglycemia or high blood glucose is known to increase the expression of miR-212-3p, possibly via calmodulin binding transcription activators CAMTA1 and 2 and its target genes, collectively increasing insulin secretion from beta cells in the pancreatic islets [87]. The gene discussed is CAMTA1; the disease is obesity due to melanocortin 4 receptor deficiency.