The mechanism behind this advantageous effect in humans is unknown, but treatment with a PPARα agonist (GW7647) also showed in mice a protective effect on myocardial contractile function after induction of cardiac ischemia [83] and treatment with a PPARα agonist (fenofibrate or ciprofibrate) in different animal models of insulin resistance (high-fat diet induced in C57BL/6 mice or genetic induced in obese Zucker rats) showed a slight improvement of glucose metabolism [84]. This evidence concerns the gene PPARA and myocardial ischemia.