This is in line with the findings from Mather et al. in T2DM individuals, who showed that the augmented myocardial fatty acid oxidation under fasted and insulin-treated conditions (measured by16-[18F]fluoro-4-thiapalmitate (FTP) and 11C-acetate) was accompanied by reduced cardiac work efficiency [47]. The gene discussed is INS; the disease is type 2 diabetes mellitus.