Considering the role of TXNIP in mediating the whole-body response to metabolic alterations, the fact that TXNIP is a marker of cardiovascular diseases and is implicated also in AD, we may speculate that TXNIP has a key role in the brain-heart axis, and it may be implicated in driving the effect of metabolic alterations in brain-heart axis, which ultimately promote AD (Figure 2). The gene discussed is TXNIP; the disease is Alzheimer disease.