Inhibition of miR-21 in TAMs reduced tumor growth by inducing proinflammatory immune responses, including TNF, CXCL10, and CXCL9 [114]; this activates CD8+ T cells and causes the secretion of cytokines and chemokines, including IL-12 and CXCL10. The gene discussed is CXCL9; the disease is neoplasm.