IFNGR1 and neoplasm: In the normal response, T cell-derived Interferon gamma (IFN-γ) binds to its receptor on the tumor cell, IFNGR1/2, then activates Janus kinase–signal transducer and activator of transcription (JAK-STAT) to induce the transcription of downstream genes including interferon-stimulated genes (ISGs) and major histocompatibility complex class I (MHC-I).