Although the first discovered family-antigen was a group of Ca2+-dependent molecules, desmogleins (Dsg) [2], over the past 20 years, more than 50 new non-desmoglein antigens have been identified as responsible for playing a role in PV pathogenesis, such as desmocollins 1 and 3, several muscarinic and nicotinic acetylcholine receptor subtypes, mitochondrial proteins, human leukocyte antigen molecules, or thyroid peroxidase [3]. Here, DSG1 is linked to acquired polycythemia vera.