Furthermore, Ikewaki et al. [20] showed that sCD93 was increased in 14 patients with chronic kidney failure compared to 10 healthy controls, and that serum sCD93 concentrations in patients were strongly positively correlated with blood urea nitrogen, serum creatinine and cystatin C. Unfortunately, these 14 chronic kidney failure patients are very poorly characterized in the report [20]. The gene discussed is CST3; the disease is chronic renal failure syndrome.