STAT3 and neoplasm: Downregulation of KCNQ1OT1 inhibits SCLC cell proliferation, migration, and invasion, induces apoptosis, and suppresses tumor growth and chemoresistance via TGF-β-mediated EMT signaling [73] and the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway [72].