Chen et al. found that KCNQ1OT1 drives SMMC-7721 and Huh7 HCC cell invasion and migration while knockdown of KCNQ1OT1 inhibits tumor growth by acting on sphingosine-1-phosphate receptor 1 (S1PR1) through miR-149 [29] (Table 1). The gene discussed is S1PR1; the disease is hepatocellular carcinoma.