Coordination chemistry along with meta-analysis and with epidemiological and genetic studies [79,81] show involvement of Cu and non-ceruloplasmin Cu (also known as ‘free’ Cu) [82], a component of serum Cu not bound to proteins and specifically not bound to ceruloplasmin, from which its name is derived, in AD, as posited by the Cu–AD hypothesis (reviewed in Reference [83]). This evidence concerns the gene CP and Alzheimer disease.