The role of the NNMT enzyme as a potential tumoral biomarker of salivary glands malignant neoplasms has been evaluated by Mori et al. The authors assessed its biological activity in a lymph node metastatic Adenoid cystic carcinoma (AdCC) cell line expressing green fluorescent protein (ACCS-LN-GFP) that was obtained by an orthotropic transplantation of submandibular metastatic AdCC cells in nude mice [34]. The gene discussed is NNMT; the disease is cancer.