Moreover, the downregulation of mesenchymal transition markers, such as Vimentin, N-cadherin, β-catenin, and p-GSK3β, the overexpression of E-cadherin, and the inhibition of Wnt/β-catenin signaling in siNNMT cells, seems to suggest the critical role of NNMT in ESCC metastasis. The gene discussed is NNMT; the disease is esophageal squamous cell carcinoma.