Regrading HSP90AA1, polyps with the lowest potential for malignancy, hyperplastic polyps and tubular adenomas, had significantly lower polyp-to normal expression ratio than polyps with polyps with higher potential for malignancy‒tubulo-villous adenomas and villous adenomas/adenocarcinomas (ρ = 0.47, p < 0.001). This evidence concerns the gene HSP90AA1 and hyperplastic polyp.