In colorectal cancer cells, the number of HSPA1 and HSP90AA1 transcripts as well as the amount of HSPA1 and, to lesser degree, HSP90AA1 protein can be altered by novel oxicam analogues containing arylpiperazine pharmacophore and benzoyl moiety substitutions at thiazine ring instead of methyl substituent at position 2 and 2-peridocarbamoyl substituent at position 3, respectively. This evidence concerns the gene HSP90AA1 and colorectal cancer.