In view of potential relevance of Hsp70α and Hsp90α in CRC chemoprevention and lack of data on their expression in precancerous polyps, we aimed to determine the ability of piroxicam and meloxicam as well as novel oxicam analogues to modulate their expression in colorectal adenocarcinoma cell lines (Caco-2, HCT 116, and HT-29) and evaluate their expression in clinical samples of colorectal neoplasms in relation to polyp potential for malignancy. Here, HSP90AA1 is linked to colorectal adenocarcinoma.