Patient were divided into two groups according to the occurrence or not of CRS and IGFBP7, TIMP-2, and [TIMP-2]∙[IGFBP7] values were significantly higher in patients with CRS (0.40 (0.25–0.71), p1: 0.049/2.40 (1.42–3.70), p2: 0.003/1.15 (0.29–2.43), p3: 0.001). The gene discussed is TIMP2; the disease is congenital rubella syndrome.