On the other hand, in cancer and CKD the role of the PTHrP/PTH1R axis has also been studied, showing that PTH and PTHrP, through the PTH1R receptor, cause the ‘browning’ of white adipose tissue plus energy production via the activation of uncoupling protein-1 (UCP-1) [21,22]. The gene discussed is UCP1; the disease is chronic kidney disease.