However, Qin et al. [25] have recently shown in a high fat diet (HFD)-induced murine obesity model that PTHrP overexpression promotes WAT browning and inhibits BAT whitening, preventing obesity, hepatic steatosis and insulin resistance [25], thereby proposing the application of PTHrP to avoid metabolic complications in obese patients. The gene discussed is PTHLH; the disease is obesity due to melanocortin 4 receptor deficiency.